https://www.dzarc.com/medical/issue/feedJournal of Advance Medical Sciences2024-01-20T10:37:58+00:00Dzarc Publications[email protected]Open Journal Systems<p><strong>Journal of Advance Medical Sciences</strong> is a peer-reviewed, refereed, and open access journal that focuses on critical and creative research and provides an open access research journal platform for scholars and researchers to exchange their research work results among professionals throughout the world. This journal publishes research articles in all fields of Medical science but is not limited to.</p>https://www.dzarc.com/medical/article/view/393Effect of quorum sensing tyrosol (antibiofilm and antibacteria) in Streptococcus mutans: narrative review2023-11-14T11:37:14+00:00Indah Listiana Kriswandini [email protected]Ira Arundina[email protected]Devy Ratriana Amiati[email protected]<p><strong>Background: </strong><em>Streptococcus mutans</em> is a gram-positive bacteria in the form of a cocci, which is a normal flora of the oral cavity. <em>Streptococcus mutans</em> forms a biofilm layer consisting of a matrix of Extracellular Polymeric Substances. Biofilm can be a health problem, one of which is dental caries. Tyrosol is <em>Quorum Sensing</em> which is owned by <em>Candida albicans</em> and has anti-biofilm and antibacterial properties on <em>Streptococcus mutans</em><em>.</em></p> <p><strong>Purpose: </strong>To analyze the effect of <em>quorum sensing</em> tyrosol (antibiofilm and antibacterial) on <em>Streptococcus mutans</em><em>.</em></p> <p><strong>Method:</strong> This study uses the narrative review method. The literature sources used come from the digital databases ScienceDirect, Pubmed, and Proquest. Inclusion criteria published in the period 2005-2022, in the form of research results or review articles, and can be accessed in full text.</p> <p><strong>Discussion: </strong>Some literature states that tyrosol can cause a decrease in <em>Streptococcus mutans</em> biofilm formation. Tyrosol synthesizes the <em>Flo8</em> gene which plays a role in hypha formation and virulence. <em>Flo8</em> can induce ALS1 to inhibit AgI/II synthesis. The phenolic content in tyrosol can suppress the production of <em>glucosyltransferases</em> produced by <em>S. mutans</em>, causing a decrease in biofilm formation, damage the cytoplasmic membrane and inhibit bacterial DNA synthesis.</p> <p><strong>Conclusion: </strong>Tyrosol can inhibit biofilm formation and antibacterial <em>S. mutans</em> by involving the <em>QS</em> mechanism. The phenolic content in tyrosol has anti-biofilm and antibacterial properties on <em>S. mutans</em><em>.</em></p>2023-10-04T00:00:00+00:00Copyright (c) 2023 Indah Listiana Kriswandini , Ira Arundina, Devy Ratriana Amiatihttps://www.dzarc.com/medical/article/view/397Assessment of nurses’ knowledge working in hemodialysis units toward infection control measures in Al-Najaf city hospitals2023-11-23T17:01:27+00:00Hussein Abdulzahra Hassooni[email protected]Müjgan Onarici[email protected]<p><strong>Background:</strong> Renal failure patients undergoing hemodialysis treatment and nursing staff working in hemodialysis units are at a significantly increased risk of healthcare-acquired infections, for example, blood-borne diseases and bacterial and fungal infections due to repeated and prolonged exposure to many potential pollutants in the hemodialysis setting. Nursing staff’s compliance with infection control and prevention measures reduces transmission; therefore, nurses working in hemodialysis units must follow standard precautions.</p> <p><strong>Objective:</strong> The aim of the study is to assess the knowledge of nurses working in hemodialysis units towards infection control measures.</p> <p><strong>Materials and Method</strong>: Quantitative design (the descriptive cross-sectional study) was used to achieve the objectives of this study. This study was conducted in the hemodialysis units at Al-Najaf city hospitals in Iraq between March 2022 and April 2022 based on a non-probability sampling (purposive sampling); the sample consisted of hundred nurses. A questionnaire was prepared as a data collection tool and consists of two parts. The first part includes the socio-demographic information of the nursing staff, and the second part contains 39 multiple-choice questions aiming to assess nurses' knowledge working in hemodialysis units about infection control measures. Descriptive and inferential statistics were used to analyze the study results using the statistical package of Social Sciences (SPSS) version 20 and Microsoft Word and Excel (2010).</p> <p><strong>Results:</strong> The study results revealed that the nurses' knowledge of the infection control measures was moderate (74,95%) and had a statistical mean score of 1,499. The findings also showed a high level of statistically significant correlation between nurses' knowledge of working in hemodialysis units and socio-demographic information in line with the critical and unique nature of hemodialysis units, such as the educational level of socio-demographic information, participation in training courses on hemodialysis units inside and outside Iraq, and participation in training courses on infection control measures training inside and outside Iraq, the number of infection control training courses, and duration of infection control training courses. The probability value was (<em>p<</em>= 0,05).</p> <p><strong>Conclusions:</strong> The study concluded that most participants had knowledge about infection control measures. A highly statistically significant correlation existed between nurses' knowledge levels and socio-demographic information. Still, because of the critical and unique nature of hemodialysis units, very strict procedures must be imposed, and nursing staff must be trained on infection control measures for hemodialysis units.</p>2023-10-10T00:00:00+00:00Copyright (c) 2023 Hussein Abdulzahra Hassooni, Dr. Müjgan Onaricihttps://www.dzarc.com/medical/article/view/399Potential of amelogenin protein in emdogain as a trigger factor for reparative dentine formation2023-11-28T08:00:39+00:00Jihan Fahira[email protected]Nur Yasmin Nadiah Binti Muhammad[email protected]Faridatul Fariza binti Ismail[email protected]Bambang Sumaryono[email protected]Sisca Meida Wati[email protected]<p><strong>Background: </strong>Profound caries with perforations due to iatrogenic factors should be treated with direct pulp capping (DPC) immediately before infection occurs due to bacterial contamination so that the prognosis will be better. Currently the material that is often used and becomes the gold standard is calcium hydroxide. The author wants to provide a material selection solution for DPC that can reduce tunnel defects, reduce inflammation, form more reparative dentin, and make work easier. One of the materials that have this ability is emdogain.</p> <p><strong>Aim: </strong>This undergraduate thesis aims to explore the potential of amelogenin as the main component of emdogain material in increasing the formation of reparative dentine.</p> <p><strong>Methodology: </strong>Literature search begins by compiling problem, intervention, comparison, and outcome (PICO). The inclusion criteria used were journals published within the last 10 years (2013-2022), types of journals research journals, case reports, and reviews, full paper accessible, and using Indonesian and English.</p> <p><strong>Results: </strong>44% of the literature supports the efficacy of emdogain as a direct pulp capping material, 72.2% of the literature supports that amelogenin protein can induce the formation of reparative dentin, and 27.7% of the literature supports minimal levels of inflammation/hypersensitivity.</p> <p><strong>Conclusion: </strong>Amelogenin in emdogain has the potential to increase reparative dentin formation by forming initiation signals resembling normal dentinogenesis processes.</p>2023-10-17T00:00:00+00:00Copyright (c) 2023 Jihan Fahira, Nur Yasmin Nadiah Binti Muhammad, Faridatul Fariza binti Ismail, Bambang Sumaryono, Sisca Meida Watihttps://www.dzarc.com/medical/article/view/425Description of the driving factors for the use of dental and oral health services at the faculty of dental and oral medicine, Airlangga University2024-01-20T10:37:58+00:00Andrea Kylila Maheswari Setiawan[email protected]Aghni Brida Anzila[email protected]Retno Pudji Rahayu[email protected]Sisca Meida Wati[email protected]Retno Palupi[email protected]<p><strong>Background: </strong><em>Streptococcus mutans </em>is a gram-positive bacteria in the form of a cocci, which is a normal flora of the oral cavity. <em>Streptococcus mutans </em>forms a biofilm layer consisting of a matrix of Extracellular Polymeric Substances. Biofilm can be a health problem, one of which is dental caries. Tyrosol is <em>Quorum Sensing </em>which is owned by <em>Candida albicans </em>and has anti-biofilm and antibacterial properties on <em>Streptococcus mutans.</em></p> <p><strong>Purpose: </strong>To analyze the effect of <em>quorum sensing </em>tyrosol (antibiofilm and antibacterial) on <em>Streptococcus mutans.</em></p> <p><strong>Method: </strong>This study uses the narrative review method. The literature sources used come from the digital databases Science Direct, Pubmed, and Proquest. Inclusion criteria published in the period 2005-2022, in the form of research results or review articles, and can be accessed in full text.</p> <p><strong>Discussion: </strong>Some literature states that tyrosol can cause a decrease in <em>Streptococcus mutans </em>biofilm formation. Tyrosol synthesizes the <em>Flo8 </em>gene which plays a role in hypha formation and virulence. <em>Flo8 </em>can induce ALS1 to inhibit AgI/II synthesis. The phenolic content in tyrosol can suppress the production of <em>glucosyltransferases </em>produced by <em>S. mutans</em>, causing a decrease in biofilm formation, damage the cytoplasmic membrane and inhibit bacterial DNA synthesis.</p> <p><strong>Conclusion: </strong>Tyrosol can inhibit biofilm formation and antibacterial <em>S. mutans </em>by involving the <em>QS </em>mechanism. The phenolic content in tyrosol has anti-biofilm and antibacterial properties on <em>S. mutans.</em></p>2023-10-20T00:00:00+00:00Copyright (c) 2023